Protein Methylation – Walsh, Christopher (2006)

Proteins can undergo posttranslational methylation (one-carbon transfer) at one or more nucleophilic side chains. Most common are methylations on nitrogen or oxygen atoms. Methylation on carboxylate side chains cover up a negative charge and add hydrophobicity. N-Methylation of lysines does not alter the cationic charge but does increase hydrophobicity. In particular, dimethylation and trimethylation of lysine side chains in proteins increase both hydrophobicity and steric bulk and can affect protein–protein interactions if they are in an interacting surface.

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